anti-41BB antibody product blog
Tags: Antibody; Monoclonal Antibody; 41BB; anti-41BB antibody;
The 41BB n/a (Catalog #MBS832095) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s 41BB can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS).FC: <= 0.5 ug/test
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Researchers should empirically determine the suitability of the 41BB n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the 41BB antibody (FITC) with the following immunoassay(s):
Flow Cytometry (Flow Cytometric analysis using 41BB antibody
Staining of ConA stimulated human peripheral blood cells with CD69 antibodyand 0.25 ug of Mouse IgG1 kappa Isotype Control (FITC) (left) or CD137 antibody (FITC) (right). Total viable cells were used for analysis.)
Mouse monoclonal 41BB antibody (FITC).
Biological Significance: This 4B4 monoclonal antibody reacts with human CD137, which is an inducible member of the TNFR family of costimulatory molecules expressed on T cells, natural killer cells, dendritic cells, granulocytes, and mast cells. Involved in recruiting TNFR-associated factors 1 and 2, CD137 signaling plays a role in T cell activation, maintaining the survival of activated and CD8 memory T cells, as well as suppressing myelopoiesis and dendritic cell development. Stimulation of this receptor has also been shown to promote expansion of CD4+CD25+ T regulatory cells ex vivo. The ligand for CD137, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. Tag/Conjugate: FITC. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing 41BB are readily searchable from our website. Different antibodies against the same target such as 41BB may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.