|The Abeta n/a (Catalog #MBS520710) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human Abeta (aa 11-16), HRPO (clone: 5E11) (Mouse IgG) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Abeta can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).
This antibody is suitable for use in ELISA (recommended dilution: 1:128K - 1:256K). This antibody has not been tested in other applications. Researchers should empirically determine the suitability of the Abeta n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Alzheimer\'s disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. It is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intra-neuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques are aggregates of the neurotoxic amyloid-beta (Abeta or Abeta) peptide. This 36-43 amino acid peptide is derived proteolytically from the transmembrane amyloid precursor protein (APP) by sequential secretase processing.
Although the normal function of Abeta is not well understood, several potential activities have been discovered including activation of kinase enzymes, protection against oxidative stress, regulation of cholesterol transport, and anti-microbial activity (potentially associated with Abeta\'s pro inflammatory activity).
Hybridoma Production: Fusion Partner: Sp2/0. Hybridoma Production: Immunization: Immunogen: (Iso-L-Asp)-DAEFR-HDSGY-EVHHQ-KLVFF-AEDV-Cys (Abeta 1-24) Donor: Balb/c spleen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Abeta are readily searchable from our website. Different antibodies against the same target such as Abeta may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.