|The ABL2 abl2 (Catalog #MBS830328) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ABL2 antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ABL2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF), Western Blot (WB).
WB: 1:500-1:2000,. Researchers should empirically determine the suitability of the ABL2 abl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ABL2 abl2 product has the following accession number(s) (GI #42406387) (NCBI Accession #AAH65912.1) (Uniprot Accession #P42684). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ABL2 antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot showing ABL2 antibody used against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY ABL2 cDNA (2).)
Mouse monoclonal ABL2 antibody.
Biological Significance: ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. c-Abl shows both cytoplasmic and nuclear localization, c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Immunogen: ABL2 antibody was raised in Mouse using a purified recombinant fragment of ABL2 expressed in E Coli as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ABL2 are readily searchable from our website. Different antibodies against the same target such as ABL2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain Diseases, Breast Neoplasms, Cell Transformation, Neoplastic, Death, Edema, Heart Diseases, Immune System Diseases, Inflammation, Kidney Diseases, Lung Neoplasms are some of the diseases may be linked to ABL2 antibody. The following patways have been known to be associated with this gene. Blood, Bone, Bone Marrow, Brain, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein.