|The ACO2 aco2 (Catalog #MBS831570) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ACO2 antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ACO2 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB).
WB: 1:2000. Researchers should empirically determine the suitability of the ACO2 aco2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ACO2 aco2 product has the following accession number(s) (GI #4501867) (NCBI Accession #NP_001089) (Uniprot Accession #Q99798). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ACO2 antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ACO2 protein (Right) or empty vector (Left) detected with ACO2 antibody)
Immunohistochemistry (IHC) (Immunohistochemical analysis of ACO2 protein in paraffin embedded Human kidney tissue using ACO2 antibody)
Mouse monoclonal ACO2 antibody.
Biological Significance: ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. Immunogen: ACO2 antibody was raised in mouse using a full length recombinant protein of human ACO2 (NP_001089) produced in HEK293T cells, as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACO2 are readily searchable from our website. Different antibodies against the same target such as ACO2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. ACO2 also interacts with the following gene(s): ACLY, FXN, IDH2. Brain Diseases, Cardiovascular Diseases, Fibrosis, Heart Diseases, Heart Failure, Inflammation, Ischemia, Lung Diseases, Lung Injury, Nervous System Diseases are some of the diseases may be linked to ACO2 antibody.