|The Activin-B inhbb (Catalog #MBS690105) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human Activin-B reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Activin-B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Neutr. Researchers should empirically determine the suitability of the Activin-B inhbb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Activin-B inhbb product has the following accession number(s) (GI #154813204) (NCBI Accession #NP_002184.2) (Uniprot Accession #P09529). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Activins and inhibins, members of the TGFbeta superfamily, are disulfide-linked dimeric proteins that were originally purified from gonadal fluids as proteins that stimulated or inhibited, respectively, pituitary follicle stimulating hormone (FSH) release. These proteins have since been shown to have a wide range of biological activities including: mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and reproductive physiology. Activins/inhibins are produced as precursor proteins with an amino-terminal propeptide that is cleaved to release the carboxy terminal bioactive ligands. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of an unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian betaA, betaB, betaC, betaE and Xenopus betaD) have been cloned. The activin/inhibin nomenclature reflects the subunit composition of the proteins: activin A (betaA beta A), activin B (betaB beta B), activin AB (betaA beta B), inhibin A (alphabeta A) and inhibin B (alphabeta B). At present, little is known about the contribution of the other beta subunits to activin or inhibin formation and biology. At the amino acid sequence level, the mature human betaB subunit is greater than 98% identical to mouse betaB, while the human and mouse alpha subunits share approximately 80% identity. Similarly to other TGFbeta family members, activins exert their biological activities through binding to the heterodimeric complex composed of two membrane spanning serinethreonine kinases designated as type I and type II. Two forms of activin receptor type I (Act RI An and Act RIB) and two forms of activin receptor type II (Act RIIA and Act RIIB) have been identified. Activin binds directly to Act RII, the complex then associates with Act RI and initiates signaling. Besides activins, Act RII has been shown to bind certain other TGFbeta superfamily members. Inhibin A has been shown to bind with lowaffinity to Act RII. The existence of a distinct inhibinspecific receptor and/or signal transduction pathway has been hypothesized.