|The ACVR2B acvr2b (Catalog #MBS2544505) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Mouse ACVR2B Monoclonal Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s ACVR2B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).
ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse ACVR2B. Researchers should empirically determine the suitability of the ACVR2B acvr2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ACVR2B acvr2b product has the following accession number(s) (GI #116734708). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
Immunogen: Recombinant Mouse ACVR2B Protein
Buffer: 0.2 mum filtered solution in PBS. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACVR2B are readily searchable from our website. Different antibodies against the same target such as ACVR2B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. ACVR2B also interacts with the following gene(s): ACVR1B, ACVRL1, BMP2, BMPR1A, INHBA, MSTN, SMAD2, SMAD3, SMAD5. Brain, Connective Tissue, Embryonic Tissue, Heart, Kidney, Lung, Ovary, Pancreas, Pituitary Gland, Testis tissues are correlated with this protein. Atrophy, Congenital Abnormalities, Disease Models, Animal, Genital Diseases, Female, Heterotaxy Syndrome, Hypertrophy, Inflammation, Nervous System Diseases, Situs Inversus, Weight Loss are some of the diseases may be linked to Rabbit anti Mouse ACVR2B Monoclonal Antibody.