|The ACY1 acy1 (Catalog #MBS2544026) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human ACY1 Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ACY1 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cyometry (FC/FACS).
Flow Cytometry: 0.5-2 mug/Test
ICC/IF: 10-25 mug/mL. Researchers should empirically determine the suitability of the ACY1 acy1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ACY1 acy1 product has the following accession number(s) (GI #312032409). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine.
Immunogen: Recombinant Human ACY1/Aminoacylase-1 protein
Buffer: 0.2 mum filtered solution in PBS with 5% trehalose. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACY1 are readily searchable from our website. Different antibodies against the same target such as ACY1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. ACY1 also interacts with the following gene(s): ASPA, GLB1, OTC, SPHK1. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Kidney, Liver, Lung, Lymph Node, Muscle, Prostate tissues are correlated with this protein. Adenocarcinoma, Aminoacylase 1 deficiency, Carcinoma, Hepatocellular, Carcinoma, Renal Cell, Congenital Abnormalities, Fibrosis, Kidney Diseases, Kidney Neoplasms, Liver Diseases, Liver Neoplasms are some of the diseases may be linked to Rabbit anti Human ACY1 Monoclonal Antibody.