anti-ACY1 antibody product blog
Tags: Antibody; Monoclonal Antibody; ACY1; anti-ACY1 antibody;
The ACY1 acy1 (Catalog #MBS830841) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s ACY1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB).FC: 1:100
IHC: 1:150
WB: 1:500-2000. Researchers should empirically determine the suitability of the ACY1 acy1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ACY1 acy1 product has the following accession number(s) (GI #4501901) (NCBI Accession #NP_000657) (Uniprot Accession #Q03154). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ACY1 antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ACY1 protein (Right) or empty vector (Left) detected with ACY1 antibody)
Immunohistochemistry (IHC) (Immunohistochemical analysis of ACY1 protein in paraffin embedded Human liver tissue using ACY1 antibody)
Mouse monoclonal ACY1 antibody.
Biological Significance: ACY1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urin ary excretion of several N-acetylated amino acids. Cross-Reactivity: Human, Mouse
Immunogen: ACY1 antibody was raised in mouse using a full length recombinant protein of human ACY1 (NP_000657) produced in HEK293 cell as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACY1 are readily searchable from our website. Different antibodies against the same target such as ACY1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Adenocarcinoma, Aminoacylase 1 deficiency, Carcinoma, Hepatocellular, Carcinoma, Renal Cell, Congenital Abnormalities, Kidney Diseases, Kidney Neoplasms, Liver Diseases, Liver Neoplasms, Neoplasm Metastasis are some of the diseases may be linked to ACY1 antibody. ACY1 also interacts with the following gene(s): ASPA, GLB1, OTC, SPHK1.