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anti-AIFM1 antibody product blog

Posted on 2016-06-04 08:33:09 by mybiosource_staff
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Tags: Antibody; AIF; Monoclonal Antibody; anti-AIFM1 antibody; AIFM1;
The AIF aifm1 (Catalog #MBS475268) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-AIF Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s AIF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF).
WB: 1:1000
ICC: 1:200. Researchers should empirically determine the suitability of the AIF aifm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The AIF aifm1 product has the following accession number(s) (GI #923424571) (NCBI Accession #NP_001124318.2) (Uniprot Accession #O95831). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-AIF Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from Hela, Ramos, HepG2, MCF7 and Jurkat cell lysates using AIF mouse mAb (1:1000 diluted).Predicted band size:67KDa.Observed band size:67KDa.)
Western Blot (WB) AIF.

Immunocytochemistry (ICC) (Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using anti-AIF mouse mAb (dilution 1:200).)
Immunocytochemistry (ICC) AIF.

Entrez Summary: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Immunogen: Purified recombinant human AIF protein fragments expressed in E Coli.
Sensitivity: This antibody detects endogenous levels of AIF and does not cross-react with related proteins.
Sequence Similarities: Belongs to the FAD-dependent oxidoreductase family. Subunit Structure: Monomer (oxidized form). Homodimer (reduced form). Also dimerizes with isoform 3 preventing its release from mitochondria. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Interacts with PRELID1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AIF are readily searchable from our website. Different antibodies against the same target such as AIF may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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