anti-ANGPT2� antibody product blog
Tags: Antibody; Monoclonal Antibody; ANGPT2�; anti-ANGPT2� antibody;
The ANGPT2� angpt2 (Catalog #MBS2544048) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human�ANGPT2� Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ANGPT2� can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP).WB: 1:500-1:1000
ICC/IF: 1:100-1:500
IP: 0.2-1 uL/mg of lysate. Researchers should empirically determine the suitability of the ANGPT2� angpt2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ANGPT2� angpt2 product has the following accession number(s) (GI #169646754). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit anti Human�ANGPT2� Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HepG2 and A549 cells, using ANGPT2 Monoclonal Antibody at dilution of 1:500.)
Immunofluorescence (IF) (Immunofluorescent analysis of A549 cells using ANGPT2 Monoclonal Antibody at dilution of 1:300.)
Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2\'s role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that ANG-2 also is critical in lymphangiogenesis during development. ANG-2 has multiple physiologic effects that regulate vascular tone, hormone secretion, tissue growth and neural activity. Several reports indicate that ANG-2 can induce neovascularization in experimental systems due to the expression of different growth factors such as angiopoietin 2, vascular endothelial factor, and its receptor, fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and epidermal growth factor.
Immunogen: Recombinant Human ANG 2 protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ANGPT2� are readily searchable from our website. Different antibodies against the same target such as ANGPT2� may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.