|The APP app (Catalog #MBS6006641) is an Antibody produced from mouse and is intended for research purposes only. The product is available for immediate purchase. The Alzheimer Precursor Protein, aa511-608 (Alz 90) reacts with Human, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Alzheimer Precursor Protein, aa511-608 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot.
Dilution: Western Blot: 10-20ug/ml. Researchers should empirically determine the suitability of the APP app for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The APP app product has the following accession number(s) (GI #4502167) (NCBI Accession #NP_000475.1) (Uniprot Accession #P05067). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Immunogen: Synthetic peptide Alz 90 (amino acids 511-608 of amyloid precursor protein pre A4695). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing APP are readily searchable from our website. Different antibodies against the same target such as APP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Brain, Heart, Intestine, Kidney, Liver, Lung, Muscle, Nerve, Vascular tissues are correlated with this protein. Alzheimer Disease, Brain Diseases, Dementia, Disease Models, Animal, Inflammation, Memory Disorders, Neoplasms, Nervous System Diseases, Neurodegenerative Diseases, Plaque, Amyloid are some of the diseases may be linked to Alzheimer Precursor Protein, aa511-608 (Alz 90). The following patways have been known to be associated with this gene.