anti-AR antibody product blog
Tags: Antibody; anti-AR antibody; Monoclonal Antibody; Androgen Receptor Protein;
The AR ar (Catalog #MBS9200671) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Androgen Receptor Protein Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Androgen Receptor Protein can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).WB~~1:100~250. Researchers should empirically determine the suitability of the AR ar for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The AR ar product has the following accession number(s) (GI #21322252) (NCBI Accession #NP_000035.2) (Uniprot Accession #P10275). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Androgen Receptor Protein Antibody with the following immunoassay(s):
Western Blot (WB) (Androgen Receptor Protein western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the AR antibody detected the AR protein (arrow).)
The androgen receptor gene is more than 90 kb long and
codes for a protein that has 3 major functional domains: the
N-terminal domain, DNA-binding domain, and androgen-binding domain.
The protein functions as a steroid-hormone activated transcription
factor. Upon binding the hormone ligand, the receptor dissociates
from accessory proteins, translocates into the nucleus, dimerizes,
and then stimulates transcription of androgen responsive genes.
This gene contains 2 polymorphic trinucleotide repeat segments that
encode polyglutamine and polyglycine tracts in the N-terminal
transactivation domain of its protein. Expansion of the
polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy
disease). Mutations in this gene are also associated with complete
androgen insensitivity (CAIS). Two alternatively spliced variants
encoding distinct isoforms have been described. [provided by
RefSeq].
Antigen Type: Recombinant Protein. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AR are readily searchable from our website. Different antibodies against the same target such as AR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein. AR also interacts with the following gene(s): CTNNB1, HSP90AA1, KLK3, NCOA1, NCOA2, NCOA3, NCOR1, RNF14, SRC, TMPRSS2. Breast Neoplasms, Heart Diseases, Hypertension, Hypertrophy, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Nervous System Diseases, Prostatic Neoplasms are some of the diseases may be linked to Androgen Receptor Protein Antibody.