|The AZU1 azu1 (Catalog #MBS584766) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Azurocidin, Human, mAb z6733 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Azurocidin can be used in a range of immunoassay formats including, but not limited to, Immuno Assay (IA).
IA: Antibody z6733 can be used both as detection and capture antibody
The typical starting working dilution is 1:50. Researchers should empirically determine the suitability of the AZU1 azu1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The AZU1 azu1 product has the following accession number(s) (GI #179302) (NCBI Accession #AAB59353.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The monoclonal antibody z6733 recognizes azurocidin (also called heparin-binding protein (HBP) or cationic antimicrobial protein of 37 Kda (CAP37). Azurocidin is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C.albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via beta2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AZU1 are readily searchable from our website. Different antibodies against the same target such as AZU1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Infectious diseases are some of the diseases may be linked to Azurocidin, Human, mAb z6733.