|The Bcan bcan (Catalog #MBS801857) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Brevican Antibody: Streptavidin reacts with Rat, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Brevican can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Western Blot (WB).
1:1000 (WB). Researchers should empirically determine the suitability of the Bcan bcan for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Bcan bcan product has the following accession number(s) (GI #75992948) (NCBI Accession #NP_001028837.1) (Uniprot Accession #P55068). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Background Info: Detects ~140kDa (and smaller due to proteolytic cleavage)
Scientific Background: Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.
Conjugate: Streptavidin. Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Bcan are readily searchable from our website. Different antibodies against the same target such as Bcan may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Breast Neoplasms, Congenital Abnormalities, Disease Models, Animal, Inflammation, Lung Diseases, Lung Neoplasms, Neoplasms, Experimental, Nervous System Diseases, Spinal Cord Diseases, Urinary Bladder Neoplasms are some of the diseases may be linked to Brevican Antibody: Streptavidin. Brain, Dorsal Root Ganglion, Eye, Pituitary Gland tissues are correlated with this protein.