|The Bcl-2 n/a (Catalog #MBS840129) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Bcl-2 Antibody (Clone Bcl-2 / 100) reacts with Human. Others are not tested. and may cross-react with other species as described in the data sheet. MyBioSource\'s Bcl-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot, Immunoprecipitation, Immunohistochemistry and Flow cytometry.
However the optimal conditions should be determined individually.
Western blot (1-4 ug/ml). Researchers should empirically determine the suitability of the Bcl-2 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Bcl-2 n/a product has the following accession number(s) (GI #179366) (NCBI Accession #AAA51813.1) (Uniprot Accession #M13994). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Background: Bcl-2 (B-cell leukemia/lymphoma 2) gene was discovered by walking the chromosomal breakpoints t(14;18). This gene consists of two exons and several transcripts that encode two different protein products, Bcl-2alpha and Bcl-2beta. Both proteins are approximately 26-30 kDa and differ at their C-terminal region. Bcl-2 suppresses apoptosis (programmed cell death) and this property appears to be modulated by homodimerization or association with Bax and Bad, two cell death promoters.
Immunogen: Synthetic peptide corresponding to resides surrounding a.a. 44 of Human Bcl-2. Handling: The antibody solution should be gently mixed before use. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Bcl-2 are readily searchable from our website. Different antibodies against the same target such as Bcl-2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.