|The CTNNB1 ctnnb1 (Catalog #MBS8510428) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The beta-Catenin Mouse Monoclonal Antibody reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s beta-Catenin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
WB: 1: 1, 000-2, 000. Researchers should empirically determine the suitability of the CTNNB1 ctnnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CTNNB1 ctnnb1 product has the following accession number(s) (GI #860988) (NCBI Accession #CAA61107.1) (Uniprot Accession #P35222). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the beta-Catenin Mouse Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of 1) Hela, 2) 293T, 3)Mouse Liver Tissue, 4) Rat Liver Tissue, with beta-Catenin Mouse mAb E12-379 diluted at 1: 2, 000.)
The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CTNNB1 are readily searchable from our website. Different antibodies against the same target such as CTNNB1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Adenocarcinoma, Adenoma, Breast Neoplasms, Carcinoma, Hepatocellular, Colonic Neoplasms, Colorectal Neoplasms, Intestinal Neoplasms, Liver Diseases, Liver Neoplasms, Neoplasm Invasiveness are some of the diseases may be linked to beta-Catenin Mouse Monoclonal Antibody. Blood, Bone, Brain, Embryonic Tissue, Intestine, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein. CTNNB1 also interacts with the following gene(s): AXIN1, CDH1, CDH2, CDH5, CTNNA1, GSK3B, LEF1, PSEN1, TCF7L2. The following patways have been known to be associated with this gene.