anti-Btk antibody product blog
Tags: Antibody; anti-BTK antibody; BTK; Monoclonal Antibody; Brutons tyrosine kinase;
The Btk btk (Catalog #MBS834567) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Brutons tyrosine kinase can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) Paraffin.WB: 1:5000. Researchers should empirically determine the suitability of the Btk btk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Btk btk product has the following accession number(s) (GI #31419802) (NCBI Accession #AAH53392.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Brutons tyrosine kinase antibody with the following immunoassay(s):
Western Blot (WB) ()
Mouse monoclonal Brutons tyrosine kinase antibody.
Biological Significance: Btk (Brutons tyrosine kinase) is a member of the Tec family of protein tyrosine kinases (PTKs) and plays a modulatory role in many cellular processes, such as proliferation, development, differentiation, survival, and apoptosis. The Tec kinases are the second largest family of non-receptor tyrosine kinases and include Tec, Btk, Bmx, Itk, and TXK/Rlk. Mutations of Btk gene cause a primary immunodeficiency disease in humans, X-linked agammaglobulinemia (XLA) which is characterized by a lack of circulating B lymphocytes and an absence of immunoglobulins as a result of defects in B cell maturation and function. Btk is found in all hematopoietic cells, with the exception of T lymphocytes and plasma cells. Btk contains amino-terminal PH (pleckstrin homology) domain which binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3) helping membrane translocation upon PI3 kinase activation. Cross-Reactivity: Human
Immunogen: Brutons tyrosine kinase antibody was raised in Mouse using a recombinant human protein purified from E Coli (His/ABD-Btk) as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Btk are readily searchable from our website. Different antibodies against the same target such as Btk may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Agammaglobulinemia, Atherosclerosis, Bruton type agammaglobulinemia, Cardiovascular Diseases, Chromosome Aberrations, Disease Models, Animal, Inflammation, Kidney Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to Brutons tyrosine kinase antibody. Blood, Bone Marrow, Embryonic Tissue, Fertilized Ovum, Liver, Lymph Node, Ovary, Pancreas, Spleen, Uncharacterized Tissue tissues are correlated with this protein.