anti-cacna1d antibody product blog
Tags: Antibody; Monoclonal Antibody; Cav1.3; anti-cacna1d antibody; cacna1d;
The cacna1d n/a (Catalog #MBS604904) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Cav1.3 (Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-gated calcium channel subunit alpha Cav1.3, Cacna1d, Calcium channel L type alpha-1 polypeptide isoform 2) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Cav1.3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC).Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
Dilution: Immunofluorescence: 1-10ug/ml
Western Blot: 1-10ug/ml. If results are poor, use lysate without boiling. Heat at 37 degree C for 15min
Immunohistochemistry: 0.1-1ug/ml
Immunocytochemistry: 0.1-1ug/ml. Researchers should empirically determine the suitability of the cacna1d n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The cacna1d n/a product has the following accession number(s) (GI #118404096) (NCBI Accession #NP_001072929.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological
The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for an unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels.
Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. Cav1.3 subunits are primarily expressed in neurons and neuroendocine cells. Some studies suggest however that Cav1.3 is also found in the atria, and may figure prominently in atrial arrhythmias (3).Cav1.3 also carries the primary sensory receptors of the mammalian cochlea, and are also expressed in the electromotile outer hair cells (4).