|The CAD dffb (Catalog #MBS832074) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CAD antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CAD can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
WB: 1:1000. Researchers should empirically determine the suitability of the CAD dffb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CAD dffb product has the following accession number(s) (GI #3410909) (NCBI Accession #BAA32250.1) (Uniprot Accession #O76075). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CAD antibody with the following immunoassay(s):
Western Blot (WB) ()
Mouse monoclonal CAD antibody.
Biological Significance: Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. Apoptosis which is a cell death process removing toxic and/or useless cells during mammalian development can be induced by a variety of stimuli, including the death factors of the tumor necrosis factor family, or UV irradiation, anticancer drugs, and survival factor deprivation. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. Immunogen: CAD antibody was raised in Mouse using a recombinant human protein purified from E Coli (His-CAD) as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CAD are readily searchable from our website. Different antibodies against the same target such as CAD may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. CAD also interacts with the following gene(s): CASP3, CIDEA, DFFA, HMGB1, HMGB2. Bone, Bone Marrow, Brain, Connective Tissue, Kidney, Liver, Lung, Skin, Testis, Vascular tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Cognition Disorders, Disease Models, Animal, Immune System Diseases, Inflammation, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to CAD antibody.