|The CCL-6 ccl6 (Catalog #MBS690479) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat Anti-Mouse CCL-6 reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CCL-6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Neutr. Researchers should empirically determine the suitability of the CCL-6 ccl6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CCL-6 ccl6 product has the following accession number(s) (GI #6677883) (NCBI Accession #NP_033165.1) (Uniprot Accession #P27784). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Mouse CCL6, a member of the beta subfamily of chemokines, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. Compared to other chemokines, mCCL6 has a large N-terminal extension. The expression of CCL6 mRNA has been detected in mouse monocytes and neutrophils, where it is strongly induced upon GM-CSF stimulation. CCL6 expression has also been detected in an IL2-dependent T cell line, where the expression is inhibited following T cell stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 in mouse macrophages. The gene for CCL6 has been mapped to mouse chromosome 11.
Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CCL-6 are readily searchable from our website. Different antibodies against the same target such as CCL-6 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Bone Marrow, Intestine, Kidney, Liver, Lung, Lymph Node, Muscle, Spleen tissues are correlated with this protein. Asthma, Disease Models, Animal, Fibrosis, Inflammation, Liver Diseases, Lung Diseases, Necrosis, Neoplasms, Nervous System Diseases, Respiratory Hypersensitivity are some of the diseases may be linked to Rat Anti-Mouse CCL-6.