anti-CCND1 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-CCND1 antibody; CCND1;
The CCND1 ccnd1 (Catalog #MBS830184) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s CCND1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).ELISA: 1:10,000
WB: 1:500-1:2000. Researchers should empirically determine the suitability of the CCND1 ccnd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CCND1 ccnd1 product has the following accession number(s) (GI #49457151) (NCBI Accession #CAG46896.1) (Uniprot Accession #Q6FI00). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CCND1 antibody with the following immunoassay(s):
Western Blot (Western Blot analysis using CCND1 antibody
Western Blot showing CCND1 antibody used against CCND1 (AA: 1-295)-hIgGFc transfected HEK293 cell lysate.)
Mouse monoclonal CCND1 antibody.
Biological Significance: During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. In a recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Cyclin D1 is also involved in development and cancer. Cyclin D1 has also been linked to the development and progression of several cancers including breast, bladder, esophagus, and lung. Cross-Reactivity: Human
Immunogen: CCND1 antibody was raised in Mouse using a purified recombinant fragment of human CCND1 expressed in E Coli as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CCND1 are readily searchable from our website. Different antibodies against the same target such as CCND1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. CCND1 also interacts with the following gene(s): CDK2, CDK4, CDK6, CDKN1A, CDKN1B, ESR1, PCNA, RB1, STAT3, UBC.