anti-CD105 antibody product blog
Tags: Antibody; Monoclonal Antibody; CD105; anti-CD105 antibody;
The CD105 eng (Catalog #MBS690417) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human CD105/Endoglin reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CD105 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC).1. Immunohistochemistry: (Paraffin) Yes (1:50-200). Researchers should empirically determine the suitability of the CD105 eng for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD105 eng product has the following accession number(s) (GI #4557555) (NCBI Accession #NP_000109.1) (Uniprot Accession #P17813). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Anti-Human CD105/Endoglin with the following immunoassay(s):
Testing Data
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF-beta1 and beta3 with high affinity but not to TGF-beta2.
Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with cell membrane glycoproteins of lymphoblastic leukemia cells. IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography. Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD105 are readily searchable from our website. Different antibodies against the same target such as CD105 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Atherosclerosis, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Hypertension, Inflammation, Liver Diseases, Necrosis, Neoplasms, Nervous System Diseases are some of the diseases may be linked to Mouse Anti-Human CD105/Endoglin. Blood, Bone, Brain, Connective Tissue, Eye, Heart, Muscle, Nerve, Skin, Vascular tissues are correlated with this protein. CD105 also interacts with the following gene(s): ACVRL1, BMP2, GIPC1, HIF1A, SMAD4, TGFB1, TGFBI, TGFBR1, TGFBR2.