anti-CD200RLa� antibody product blog
Tags: Antibody; Monoclonal Antibody; CD200RLa�; anti-CD200RLa� antibody;
The CD200RLa� n/a (Catalog #MBS2544262) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human�CD200RLa� Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CD200RLa� can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CD200R1L. The detection limit for Human CD200R1L is approximately 0.00245 ng/well. Researchers should empirically determine the suitability of the CD200RLa� n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Cell surface glycoprotein CD200 receptor 2, also known as Cell surface glycoprotein CD200 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD200 receptor-like 2, CD200Rla, CD200R1L and CD200R2, is a single-pass type I� membrane protein which belongs to the�CD200R family. CD200R1L/CD200R2. It contains one�Ig-like C2-type (immunoglobulin-like) domain and one�Ig-like V-type (immunoglobulin-like) domain. CD200 is a transmembrane protein delivering immunoregulatory signals after engagement of CD200R. A family of CD200Rs exist (CD200R1, CD200R2, CD200R3, CD200R4) with different tissue expression and functional activity. In the presence of anti-CD200R2/CD200R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD200 and one of its receptors, CD200R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3 (+) regulatory T cells. Unlike anti-CD200R1, anti-CD200R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg.
Immunogen: Recombinant Human CD200R1L protein
Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human CD200R1L (rh CD200R1L; AAT00538.1; Met1-Leu239). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD200RLa� are readily searchable from our website. Different antibodies against the same target such as CD200RLa� may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.