anti-CD274� antibody product blog
Tags: Antibody; Monoclonal Antibody; CD274�; anti-CD274� antibody;
The CD274� cd274 (Catalog #MBS2544430) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Mouse�CD274� Monoclonal Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CD274� can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cyometry (FC/FACS).Flow Cytometry: 0.5-2 mug/Test
ICC/IF: 10-25 mug/mL. Researchers should empirically determine the suitability of the CD274� cd274 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD274� cd274 product has the following accession number(s) (GI #112363645). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1 (PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Immunogen: Recombinant Mouse PD-L1/B7-H1/CD274 protein
Buffer: 0.2 mum filtered solution in PBS. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD274� are readily searchable from our website. Different antibodies against the same target such as CD274� may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CD274� also interacts with the following gene(s): CD80, HLA-DRB1, LCK, PDCD1, PDCD1LG2, PTPN11. The following patways have been known to be associated with this gene. Adenocarcinoma, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, Lung Neoplasms, Necrosis, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to Rabbit anti Mouse�CD274� Monoclonal Antibody.