anti-CD38 antibody product blog
Tags: Antibody; Monoclonal Antibody; CD38; anti-CD38 antibody;
The CD38 cd38 (Catalog #MBS5309444) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The CD38 antibody (allophycocyanin) reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CD38 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS).FC/FACS: = 0.5 ug/test
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Researchers should empirically determine the suitability of the CD38 cd38 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD38 cd38 product has the following accession number(s) (GI #1911103) (NCBI Accession #BAA18966.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CD38 antibody (allophycocyanin) with the following immunoassay(s):
Flow Cytometry (FC/FACS) (Staining of C57Bl/6 splenocytes with CD3e antibody (FITC) and 0.03 ug of Rat IgG2a K Isotype Control (left) or 0.03 ug of CD38 antibody (right). Cells in the lymphocyte gate were used for analysis.)
The 90 monoclonal antibody reacts with the mouse CD38 molecule, an ~42 kDa type II transmembrane protein. CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. Its expression is reported on a subpopulation of thymocytes, mature T cells, and NK cells. Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhanced by co-signals such as IL-4 and LPS. CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a role in lymphocyte activation and differentiation.
Conjugate: APC. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD38 are readily searchable from our website. Different antibodies against the same target such as CD38 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.