|The CD44 cd44 (Catalog #MBS2533851) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Anti-Mouse CD44 Antibody (PerCP conjugated) reacts with Mouse and may cross-react with other species as described in the data sheet.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used <= 0.5 ug /106 cells in 100 ul). Since applications vary, the appropriate dilutions must be determined for individual use. Researchers should empirically determine the suitability of the CD44 cd44 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD44 cd44 product has the following accession number(s) (GI #685122) (NCBI Accession #AAB30429.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Mouse CD44 Antibody (PerCP conjugated) with the following immunoassay(s):
Flow Cytometry (FC/FACS) (C57BL/6 mouse splenocytes CD4+ stained with PE anti-mouse CD62L and PerCP anti-mouse CD44)
CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.
Conjugation: PerCP. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD44 are readily searchable from our website. Different antibodies against the same target such as CD44 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CD44 also interacts with the following gene(s): ERBB2, HMMR, ICAM1, LCK, MMP9, MSN, NF2, SELE, SPP1. Blood, Bone, Bone Marrow, Embryonic Tissue, Liver, Lung, Lymph Node, Skin, Spleen, Vascular tissues are correlated with this protein. Breast Neoplasms, Carcinoma, Disease Models, Animal, Inflammation, Lung Diseases, Lung Neoplasms, Necrosis, Neoplasm Metastasis, Neoplasms, Experimental, Skin Diseases are some of the diseases may be linked to Anti-Mouse CD44 Antibody (PerCP conjugated). The following patways have been known to be associated with this gene.