anti-CD62L antibody product blog
Tags: Antibody; Monoclonal Antibody; CD62L; anti-CD62L antibody;
The CD62L n/a (Catalog #MBS520193) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Rat CD62L FITC (Clone OX-85) (mouse IgG1) reacts with Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s CD62L can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), ELISA (EIA). Researchers should empirically determine the suitability of the CD62L n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Rat CD62L FITC (Clone OX-85) (mouse IgG1) with the following immunoassay(s):
Testing Data
FITC anti-rat CD62L monoclonal antibody recognizes rat leukocyte selectin (L-selectin). CD62L is expressed constitutively on leukocytes and is expressed by a subset of thymocytes predominantly single positive CD4 or CD8 cells and a majority of lymph node cells in rats. CD62L binds well to O-glycans present on certain glycoforms of the mucins GlyCAM-1, CD34 and MAdCAM-1. CD62L is reported to be capable of reported to be capable of capable of transducing signals when cross-linked and has been shown to stimulate beta2-integrin-mediated adhesion when bound to soluble GlyCAM-1. [1] L-selectin expressing CD4+CD8- thymocytes were shown through adoptive transfer to protect rats from insulin-dependent diabetes. CD4+CD8- thymocytes must mature to the stage of L-selectin expression before they can mediate normal T cell function. [2] Sensitive detection systems may be required on some tissues as expression of rat CD62L is weak.
Immunogen: Recombinant rat L-selectin
Donor: BALB/c Spleen
Fusion Partner: NSI/1. Presentation: 100ug or 500ug FITC conjugated Ig buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD62L are readily searchable from our website. Different antibodies against the same target such as CD62L may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.