|The CD8 n/a (Catalog #MBS140153) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase.
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Introduction: CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains bind to class-I MHC molecules alpha-3 domains.
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Immunogen: Purified Mouse LN T cells.
Antibody Properties: FACS staining, immunohistochemistry, Western Blotting. For staining, use 10 ul/1,000,000 cells.
Available Conjugates: This antibody is only available unconjugated and conjugated to Biotin. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD8 are readily searchable from our website. Different antibodies against the same target such as CD8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.