|The CD80 cd80 (Catalog #MBS2534256) is an Antibody produced from Hamster and is intended for research purposes only. The product is available for immediate purchase. The Anti-Mouse CD80 Antibody (PE conjugated) reacts with Mouse and may cross-react with other species as described in the data sheet.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used <= 0.5 ug /106 cells in 100 ul). Since applications vary, the appropriate dilutions must be determined for individual use. Researchers should empirically determine the suitability of the CD80 cd80 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD80 cd80 product has the following accession number(s) (GI #18072037) (NCBI Accession #AAL58443.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Mouse CD80 Antibody (PE conjugated) with the following immunoassay(s):
Flow Cytometry (FC/FACS) (LPS (3-day) stimulated C57BL/6 mouse splenocytes stained with PE anti-mouse CD80)
CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.
Conjugation: PE. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD80 are readily searchable from our website. Different antibodies against the same target such as CD80 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.