|The CDK4 cdk4 (Catalog #MBS533312) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CDK4 antibody reacts with Pig, Rat, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CDK4 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Western Blot (WB). Researchers should empirically determine the suitability of the CDK4 cdk4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CDK4 cdk4 product has the following accession number(s) (GI #4502735) (NCBI Accession #NP_000066.1) (Uniprot Accession #P11802). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Mouse monoclonal CDK4 antibody.
Biological Significance: Cyclin-dependent kinases (CDKs) are a family of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. CDK4 deficiency has been linked to insulin deficient diabetes. Immunogen: Cyclin Dependent Kinase 4 antibody was raised in mouse using human recombinant full-length cdk4 polypeptide as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CDK4 are readily searchable from our website. Different antibodies against the same target such as CDK4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Kidney, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein. CDK4 also interacts with the following gene(s): CCND1, CCND2, CCND3, CDC37, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, RB1. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Nervous System Diseases, Skin Neoplasms are some of the diseases may be linked to CDK4 antibody.