|The CENPA cenpa (Catalog #MBS601023) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CENP-A (Centromere Protein A) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CENP-A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC).
Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Dilution: Western Blot: 1ug/ml
Optimal dilutions to be determined by researcher. Researchers should empirically determine the suitability of the CENPA cenpa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CENPA cenpa product has the following accession number(s) (GI #1841749) (NCBI Accession #AAB47505.1) (Uniprot Accession #P49450). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Centromere protein A (CENP-A) is a 17-19kD centromere-specific histone variant that is 62% identical to the carboxy-terminal domain of histone H3. In the presence of DNA CENP-A forms an octameric complex with histones H4, H2A, and H2B. CENP-A defines active centromere regions by forming centromere-specific nucleosomes on which kinetochores are assembled. CENP-An is specifically located to the inner plate of the kinetochore and it is essential for kinetochore targeting of CENP-C and other kinetochore components. CENP-An is required for nucleosomal packaging of centromeric DNA at interphase.
Immunogen: Synthetic peptide corresponding to a portion of human CENP-A. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CENPA are readily searchable from our website. Different antibodies against the same target such as CENPA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CENPA also interacts with the following gene(s): AURKB, BIRC5, CENPE, CENPF, HJURP, NUF2. The following patways have been known to be associated with this gene. Blood, Connective Tissue, Embryonic Tissue, Liver, Lung, Lymph, Lymph Node tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Hypertension, Liver Cirrhosis, Liver Diseases, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms are some of the diseases may be linked to CENP-A (Centromere Protein A).