|The CFB cfb (Catalog #MBS520699) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human Complement Factor B/Bb, FITC (clone: M13/12), (Mouse IgG1 K) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Complement Factor B/Bb can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
This antibody is suitable for use in Western Blot, ELISA (1:32K-1:64K) and Immunoprecipitation. Researchers should empirically determine the suitability of the CFB cfb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CFB cfb product has the following accession number(s) (GI #67782358) (NCBI Accession #NP_001701.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Anti-human complement factor B/Bb recognizes human complement factor B and its\' cleavage product Bb. Complement factor B is a single-chain molecule of 764 amino acids (MW of 90 kDa) and is part of the alternative complement pathway. It is cleaved by Factor D yielding the non-catalytic Ba and the serine protease Bb. Bb associates with C3b and provides the catalytic subunit of the C5 convertase which cleaves C5 to C5a and C5b.
Factor B is an acute-phase protein whose levels increase during inflammation. Additionally, Bb is involved in the proliferation and differentiation of pre-activated B-lymphocytes. Conversely, Ba has been shown to inhibit the proliferation of pre-activated B-lymphocytes.
Hybridoma Production: Immunization: Immunization: Mouse monoclonal antibody raised against human complement factor B/Bb.
Isotype Control: CLCMG101. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CFB are readily searchable from our website. Different antibodies against the same target such as CFB may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CFB also interacts with the following gene(s): ARMS2, C4B, CFP. Atypical Hemolytic Uremic Syndrome, Cardiovascular Diseases, Fibrosis, Heart Diseases, Immune System Diseases, Inflammation, Kidney Diseases, Macular Degeneration, Necrosis, Nervous System Diseases are some of the diseases may be linked to Anti-Human Complement Factor B/Bb, FITC (clone: M13/12), (Mouse IgG1 K). The following patways have been known to be associated with this gene.