anti-CFHR1-2 antibody product blog
Tags: Antibody; Monoclonal Antibody; CFHR1-2; anti-CFHR1-2 antibody;
The CFHR1-2 cfhr1 (Catalog #MBS584696) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CFHR1-2, Human, mAb JHD-7.10.1 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CFHR1-2 can be used in a range of immunoassay formats including, but not limited to, Immuno Assay (IA), Western Blot (WB).For Immuno Assays and Western Blot, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Researchers should empirically determine the suitability of the CFHR1-2 cfhr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CFHR1-2 cfhr1 product has the following accession number(s) (GI #118442839) (NCBI Accession #NP_002104.2) (Uniprot Accession #Q03591). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The monoclonal antibody JHD-7.10.1 reacts with human complement factor H-related protein 1 and 2 (CFHR1/2). In humans the complement factor H protein family consists of complement factor H, the factor H-like protein 1 and five factor H-related proteins termed 1 to 5. All members of this group are expressed primarily in the liver and subsequently secreted into plasma. The secreted forms of these proteins are composed exclusively of repetitive protein domains termed short consensus repeats (SCR). The CFHR1 protein is composed of five SCR domains and circulates in plasma as two differentially glycosylated isoforms (37 kDa and 43 kDa). CFHR-2 is composed of four SCRs and is present in human plasma in a non-glycosylated form (24 kDa) and a glycosylated form of 29 kDa. So far the biological functions of both CFHR-1 and CFHR-2 proteins are poorly understood, however recent studies have shown that CFHR1 is a complement regulator that blocks C5 convertase activity as well as assembly and membrane insertion of the terminal components. Moreover, genetic variations in the CFHR1 gene are associated with several diseases such as atypical hemolytic uremic syndrome and age-related macular degeneration. Due to a high degree of amino acid sequence homology the monoclonal antibody is cross-reactive with both CFHR1 and 2. The antibody is suitable for immunoassay and Western blot applications.