|The Chem R23 cmklr1 (Catalog #MBS690738) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human Chem R23 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Chem R23 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the Chem R23 cmklr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Chem R23 cmklr1 product has the following accession number(s) (GI #215272317) (NCBI Accession #NP_001135815.1) (Uniprot Accession #Q99788). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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ChemR23, also known as Dez in mouse, is a seven-pass transmembrane, G-protein-associated receptor related to the chemoattractant C3a and C5a complement receptors. Although it shows less than 30% amino acid identity to the chemokine receptor family, it shows significant structural similarity. ChemR23 expression is limited to macrophages and dendritic cells. A ligand for ChemR23 has been identified as Chemerin, also known as Tig-2. Receptor-ligand binding elicits chemotaxis of macrophages and immature, but not mature, dendritic cells.
Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Chem R23. Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Chem R23 are readily searchable from our website. Different antibodies against the same target such as Chem R23 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adipose Tissue, Blood, Bone, Brain, Connective Tissue, Heart, Kidney, Lung, Spleen, Uterus tissues are correlated with this protein. Atherosclerosis, Cardiovascular Diseases, Disease Models, Animal, Fatty Liver, Inflammation, Insulin Resistance, Liver Diseases, Lung Diseases, Necrosis, Pain are some of the diseases may be linked to Mouse Anti-Human Chem R23. Chem R23 also interacts with the following gene(s): RARRES2.