anti-CHGA antibody product blog
Tags: Antibody; Chromogranin A; CHGA; Monoclonal Antibody; anti-CHGA antibody;
The CHGA chga (Catalog #MBS570093) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti Chromogranin A reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Chromogranin A can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin).LK2H10 is useful for immunohistochemistry on paraffin embedded and frozen tissues. Optimal antibody dilution should be determined by titRation; recommended dilution 1:10 when applied in the Indirect immunofluorescence method. With the ABC method the dilution can be 5-10x higher. Dilute immediately before use with PBS or TRIS-HCl pH 7,0. Researchers should empirically determine the suitability of the CHGA chga for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CHGA chga product has the following accession number(s) (GI #4502805) (NCBI Accession #NP_001266.1) (Uniprot Accession #P10645). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Neurons and neuroendocrine cells contain membrane-delimited pools of peptide hormones, biogenic amines, and neurotransmitters with a characteristic electron-dense appearance. These vesicles, which are present throughout the neuroendocrine system and in a variety of neurons, store and release chromogranins and secretogranins, an unique group of acidic, soluble secretory proteins. Chromogranin A, a protein of 439 amino acids which is encoded on chromosome 14, and an apparent molecular weight of 68kDa, is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors, including small cell lung carcinoma.
Source Note: LK2H10 is a Mouse monoclonal IgG1 antibody derived by fusion of NS-1 Mouse myeloma cells with spleen cells from a BABL/c Mouse immunized with an immunogen that has been isolated from Human pheochromocytoma. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CHGA are readily searchable from our website. Different antibodies against the same target such as CHGA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Adrenal Gland, Brain, Kidney, Lung, Nerve, Pancreas, Parathyroid, Prostate, Stomach, Thyroid tissues are correlated with this protein.