anti-Chk1 antibody product blog
Tags: Antibody; anti-Chk1 antibody; Chk1; Monoclonal Antibody;
The CHEK1 chek1 (Catalog #MBS2540176) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CHEK1 Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s CHEK1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA).WB: 1:500-1:5000
IHC: 1:20-1:200. Researchers should empirically determine the suitability of the CHEK1 chek1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CHEK1 chek1 product has the following accession number(s) (GI #166295194) (NCBI Accession #NP_001107593.1) (Uniprot Accession #O14757). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CHEK1 Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HeLa cells using Chk1 Monoclonal Antibody at dilution of 1:1000)
CHEK1(Checkpoint kinase-1) is also named as CHK1 and belongs to the protein kinase superfamily. It is implicated in a circuit in which it activates checkpoints, DNA repair and proliferating cell nuclear antigen and FANCD2 monoubiquitinylation. CHEK1 protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol. It has 3 isoforms produced by alternative splicing with the molecular mass of 54 kDa, 44 kDa and 50 kDa.
Immunogen: Fusion protein of Chk1. Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Conjugation: Unconjugated. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CHEK1 are readily searchable from our website. Different antibodies against the same target such as CHEK1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinoma, Colonic Neoplasms, Drug Toxicity, Hyperplasia, Liver Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms are some of the diseases may be linked to CHEK1 Monoclonal Antibody. CHEK1 also interacts with the following gene(s): AKT1, ATM, ATR, CDC25A, CDC25C, E2F1, E2F4, RAD51, TP53, XRCC6. Brain, Lung, Prostate tissues are correlated with this protein.