anti-CK1 antibody product blog
Tags: Antibody; Monoclonal Antibody; CK1; anti-CK1 antibody;
The CK1 csnk1a1 (Catalog #MBS850680) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CK1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CK1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA).WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000. Researchers should empirically determine the suitability of the CK1 csnk1a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CK1 csnk1a1 product has the following accession number(s) (GI #68303575) (NCBI Accession #NP_001020276.1) (Uniprot Accession #P48729). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CK1 Antibody with the following immunoassay(s):
Western Blot (WB) (Figure 1. Western blot analysis using CK1 mouse mAb against truncated CK1 recombinant protein.)
Immunohistochemistry (IHC) (Figure 2. Immunohistochemical analysis of paraffin-embedded human liver tissue (A), colon carcinoma (B), lung carcinoma (C) and esophagus tissue (D), showing membrane localization using CK1 mouse mAb with DAB staining.)
CK1 (also designated Cytokeratin 1 or KRT1), with 644-amino acid protein (about 70kDa), is a member of the keratin family. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells.CK1 consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. CK1 is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma.
Immunogen: Purified recombinant fragment of CK1 expressed in E. Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CK1 are readily searchable from our website. Different antibodies against the same target such as CK1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Anemia, Breast Neoplasms, Cell Transformation, Neoplastic, Drug Toxicity, Neoplasms are some of the diseases may be linked to CK1 Antibody.