anti-CLDN16 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-CLDN16 antibody; CLDN16;
The CLDN16 cldn16 (Catalog #MBS6010710) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CLDN16 (PCLN1, Claudin-16, Paracellin-1, HOMG3, PCLN-1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CLDN16 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the CLDN16 cldn16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CLDN16 cldn16 product has the following accession number(s) (GI #5729970) (NCBI Accession #NP_006571.1) (Uniprot Accession #Q9Y5I7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MTSRTPLLVT ACLYYSYCNS RHLQQGVRKS KRPVFSHCQV PETQKTDTRH LSGARAGVCP CCHPDGLLAT MRD.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CLDN16 (PCLN1, Claudin-16, Paracellin-1, HOMG3, PCLN-1) with the following immunoassay(s):
Western Blot (WB) (Western Blot detection against Immunogen (34.14kD).)
Western Blot (WB) (Western Blot analysis of CLDN16 expression in transfected 293T cell line by CLDN16 monoclonal antibody.|Lane 1: CLDN16 transfected lysate (33.8kD).|Lane 2: Non-transfected lysate.)
Testing Data (Detection limit for recombinant GST tagged CLDN16 is 0.3ng/ml as a capture antibody.)
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
Immunogen: Partial recombinant corresponding to aa1-73 from human CLDN16 (NP_006571) with GST tag. MW of the GST tag alone is 26kD. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CLDN16 are readily searchable from our website. Different antibodies against the same target such as CLDN16 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Cell Transformation, Neoplastic, Congenital Abnormalities, HYPOMAGNESEMIA 3, RENAL, Necrosis, Neoplasms, Nervous System Diseases, Ovarian Neoplasms are some of the diseases may be linked to CLDN16 (PCLN1, Claudin-16, Paracellin-1, HOMG3, PCLN-1).