|The CMKLR1 cmklr1 (Catalog #MBS631794) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The CMKLR1 (Chemokine-Like Receptor 1, CHEMERINR, ChemR23, DEZ, G Protein Coupled Receptor ChemR23, G Protein Coupled Receptor DEZ, MGC126105, MGC126106) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CMKLR1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS).
Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: 1:25-1:100; 10ul labels 10e6 cells in 100ul. Researchers should empirically determine the suitability of the CMKLR1 cmklr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CMKLR1 cmklr1 product has the following accession number(s) (GI #215272321) (NCBI Accession #NP_001135817.1) (Uniprot Accession #Q99788). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Serpentine chemokine-like receptor 1 (CMKLR1) is a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, lymphocytes, monocytes or granulocytes. Studies show that CMKLR1 is also expressed on dendritic cells, which have been generated in vitro from monocytes. The sole ligand for CMKLR1 is chemerin, a chemoattractant that exists at the mRNA level in a wide range of tissues, and as an inactive proform in serum and plasma. Studies suggest that chemerin, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDC\'s are recruited to sites of bleeding and tissue damage.
Immunogen: Peptide corresponding to an epitope within the N-terminal region of human CMKLR1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CMKLR1 are readily searchable from our website. Different antibodies against the same target such as CMKLR1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adipose Tissue, Blood, Bone, Brain, Connective Tissue, Heart, Kidney, Lung, Spleen, Uterus tissues are correlated with this protein. Cardiovascular Diseases, Diabetes Mellitus, Inflammation, Insulin Resistance, Lung Diseases, Neoplasms, Obesity, Pain, Peritonitis, Reperfusion Injury are some of the diseases may be linked to CMKLR1 (Chemokine-Like Receptor 1, CHEMERINR, ChemR23, DEZ, G Protein Coupled Receptor ChemR23, G Protein Coupled Receptor DEZ, MGC126105, MGC126106).