|The CREBBP cbp (Catalog #MBS632629) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CBP, p300 (CREB Binding Protein, Histone Acetyl Transferase, RTS, RSTS, Rubinstein-Taybi Syndrome) reacts with Human, Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s CBP, p300 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF).
Suitable for use in Immunofluorescence and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin/paraffin): 1:25-1:50 for 20 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Researchers should empirically determine the suitability of the CREBBP cbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CREBBP cbp product has the following accession number(s) (GI #3168627) (Uniprot Accession #O60424). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
p300 is a transcriptional adapter protein which is characterized by three cysteine-and histidine-rich regions and its C-terminus specifically binds the adenovirus E1A protein. p300, and p300-associated proteins, are components of TATAbinding protein (TBP) complexes. Protein kinase A mediated CREB phosphorylation results in the binding of CREB to a 265kD nuclear protein designated CBP (for CREB-binding protein). CBP and p300 are homologous to each other.
Immunogen: Purified p300 protein. Epitope: aa2071-2091. MW of Antigen: 300kD. Cellular Localization: Nuclear. Positive Control: Tonsil. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CREBBP are readily searchable from our website. Different antibodies against the same target such as CREBBP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. CREBBP also interacts with the following gene(s): EP300, JUN, MLL, MYB, NCOA1, NCOA2, NCOA3, PML, RELA, STAT1. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Nerve, Thyroid tissues are correlated with this protein. Bone Diseases, Developmental, Carcinoma, Craniofacial Abnormalities, Leukemia, Leukemia, Myeloid, Leukemia, Myeloid, Acute, Necrosis, Neoplasms, Neurodegenerative Diseases, Rubinstein-Taybi Syndrome are some of the diseases may be linked to CBP, p300 (CREB Binding Protein, Histone Acetyl Transferase, RTS, RSTS, Rubinstein-Taybi Syndrome).