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anti-CREST antibody product blog

Posted on 2016-06-21 16:31:33 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; CREST; anti-CREST antibody;
The CREST n/a (Catalog #MBS768204) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CREST Mouse Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CREST can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
WB : 1:1000-1:6000. Researchers should empirically determine the suitability of the CREST n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The CREST n/a product has the following accession number(s) (Uniprot Accession #O75177). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CREST Mouse Monoclonal with the following immunoassay(s):
SDS-PAGE (NIH/3T3 cells were subjected to SDS PAGE followed by western blot with MBS768204 (CREST antibody) at dilution of 1:3000)

Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).

Immunogen: Synovial sarcoma translocation gene on chromosome 18-like 1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CREST are readily searchable from our website. Different antibodies against the same target such as CREST may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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