anti-CRK antibody product blog
Tags: Antibody; Monoclonal Antibody; CRK; anti-CRK antibody;
The CRK crk (Catalog #MBS476205) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-CRK Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CRK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the CRK crk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The CRK crk product has the following accession number(s) (GI #958893621) (NCBI Accession #JAO95579.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-CRK Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using CRK mAb against human CRK (AA)
Western Blot (WB) (Western blot analysis using CRK mAb against HEK293 (1) and CRK (AA)
Immunofluorescence (IF) (Immunofluorescence analysis of 3T3-L1 cells using CRK mouse mAb (green). Blue)
Flow Cytometry (FC/FACS) (Flow cytometric analysis of Hela cells using CRK mouse mAb (blue) and negative control (red).)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded intima cancer tissues using CRK mouse mAb with DAB staining.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded lung cancer tissues using CRK mouse mAb with DAB staining.)
Entrez Summary: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Immunogen: Purified recombinant fragment of human CRK expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CRK are readily searchable from our website. Different antibodies against the same target such as CRK may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.