anti-CRTC3 antibody product blog
Tags: Antibody; Monoclonal Antibody; CRTC3; anti-CRTC3 antibody;
The CRTC3 crtc3 (Catalog #MBS476133) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-CRTC3 Mouse mAb reacts with Human, Monkey and may cross-react with other species as described in the data sheet. MyBioSource\'s CRTC3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the CRTC3 crtc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The CRTC3 crtc3 product has the following accession number(s) (GI #110431354) (NCBI Accession #NP_073606.3) (Uniprot Accession #Q6UUV7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-CRTC3 Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using CRTC3 mouse mAb against Hela (1), Jurkat (2), Cos7 (3) and MCF-7 (4) cell lysate.)
Immunofluorescence (IF) (Immunofluorescence analysis of NTERA-2 cells using CRTC3 mouse mAb (green). Red)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded breast cancer (left) and ovarian cancer (right) using CRTC3 mouse mAb with DAB staining.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded lung cancer (left) and esophagus cancer (right) using CRTC3 mouse mAb with DAB staining.)
Entrez Summary: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 \'Ser-133\' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
Immunogen: Purified recombinant fragment of human CRTC3 expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CRTC3 are readily searchable from our website. Different antibodies against the same target such as CRTC3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.