anti-CX3CR1 antibody product blog
Tags: Antibody; Monoclonal Antibody; CX3CR1; anti-CX3CR1 antibody;
The CX3CR1 cx3cr1 (Catalog #MBS833025) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s CX3CR1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS).FC: <= 0.25 ug/test
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Researchers should empirically determine the suitability of the CX3CR1 cx3cr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CX3CR1 cx3cr1 product has the following accession number(s) (GI #1351394) (NCBI Accession #P49238.1) (Uniprot Accession #P49238). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CX3CR1 antibody (biotin) with the following immunoassay(s):
Flow Cytometry (FC/FACS) (Staining of normal human peripheral blood cells with 0.125 ug of Rat IgG2b Isotype Control (biotin) (left) or 0.125 ug of Anti-Human CX3CR1 (biotin) (right) followed by Streptavidin (PE). Samples were subsequently stained intracellularly with Anti-Human perforin (FITC). Cells were gated on CD16+CD56+ using CD16 antibody (eFluor 450) and CD56 antibody (APC).)
Rat monoclonal CX3CR1 antibody (biotin).
Biological Significance: This 2A9-1 monoclonal antibody reacts with human CX3CR1, which is the receptor for fractalkine, a transmembrane chemokine of the CX3C family. CX3CR1 is a seven transmembrane G protein-coupled receptor expressed on CD16+ NK cells, T cells, and monocytes. In non-immune cells, CX3CR1 has been found on osteoclast precursors and microglia. Little to no CX3CR1 surface expression can be detected on B cells and granulocytes. Together, fractalkine and its receptor mediate cell-cell adhesion and chemotaxis of NK cells, T cells, and monocytes. The expression of CX3CR1 has also been correlated with high levels of intracellular perforin and granzyme B. Tag/Conjugate: Biotin. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CX3CR1 are readily searchable from our website. Different antibodies against the same target such as CX3CR1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Atherosclerosis, Coronary Disease, Disease Models, Animal, HIV Infections, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to CX3CR1 antibody (biotin). CX3CR1 also interacts with the following gene(s): CCL11, CCL17, CCL2, CCL22, CCL3, CCL5, CX3CL1, CXCL10, CXCL12, CXCL16. The following patways have been known to be associated with this gene. Blood, Brain, Connective Tissue, Kidney, Liver, Lung, Pancreas, Spinal Cord, Spleen, Thymus tissues are correlated with this protein.