anti-DES antibody product blog
Tags: Antibody; DES; Monoclonal Antibody; anti-DES antibody; Desmin;
The DES des (Catalog #MBS475712) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Desmin Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Desmin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the DES des for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The DES des product has the following accession number(s) (GI #55749932) (NCBI Accession #NP_001918.3) (Uniprot Accession #P17661). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Desmin Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using Desmin mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY Desmin cDNA (2).)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human smooth musde sarcoma, showing cytoplasmic localization using Desmin mouse mAb with DAB staining.)
Entrez Summary: Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.
Immunogen: Purified recombinant fragment of Desmin expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DES are readily searchable from our website. Different antibodies against the same target such as DES may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Heart, Liver, Lung, Muscle, Nerve, Skin, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. DES also interacts with the following gene(s): AURKB, CAPN1, DSP, NEB, PKD1, ROCK1, S100A1, S100B, SHBG.