anti-DJ1/Park antibody product blog
Tags: Antibody; Monoclonal Antibody; DJ1/Park; anti-DJ1/Park antibody;
The DJ1/Park dj1 (Catalog #MBS555673) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The DJ1/Park, monoclonal antibody, mouse reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s DJ1/Park can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the DJ1/Park dj1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The DJ1/Park dj1 product has the following accession number(s) (GI #269927016) (NCBI Accession #ACZ52888.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the DJ1/Park, monoclonal antibody, mouse with the following immunoassay(s):
Testing Data (Image: HeLa cells stained (green), and chicken antibody to vimentin (red) and DNA (blue). antibody reveals strong cytoplasmic staining for DJ-1 in human cells, but does not bind to rodent cells)
Testing Data (Image: Blot of 20 ug rat brain lysate (lane 1) and 20 ug HeLa cell lysate (lane 2) was probed with antibody to DJ-1at 1:5,000. Notes that the strong single band running at about 21kDa corresponds to DJ-1 in HeLa cells, while DJ-1 is barely seen in rat brain lysate. This antibody binds also to bovine DJ-1 on western blots but does not recognize rat or mouse DJ-1.)
DJ-1, also known as Park7, is a cytoplasmic protein that belongs to the ThiJ/Pfp1/DJ1 superfamily that functions as protein chaperones, catalases, proteases and kinases. DJ-1 was originally cloned as an oncogene that cooperatively transforms cells together with H-ras. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson\'s disease. DJ-1 may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson\'s disease and acute damage such as stroke.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DJ1/Park are readily searchable from our website. Different antibodies against the same target such as DJ1/Park may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.