anti-Dtk antibody product blog
Tags: Antibody; Monoclonal Antibody; Dtk; anti-Dtk antibody;
The Dtk tyro3 (Catalog #MBS691033) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat Anti-Mouse Dtk reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Dtk can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) - Formalin.1. Western blot: Yes (1:100-1000) 2. IHC (Frozen): Yes (1:50-400). Researchers should empirically determine the suitability of the Dtk tyro3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Dtk tyro3 product has the following accession number(s) (GI #68989243) (NCBI Accession #NP_062265.2) (Uniprot Accession #P55144). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk) constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anti-coagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.
Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified recombinant mouse Dtk extracellular domain. IgG1 fraction of culture supernatant was purified by Protein G affinity chromatography. Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Dtk are readily searchable from our website. Different antibodies against the same target such as Dtk may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Abnormalities, Drug-Induced, Brain Diseases, Breast Neoplasms, Cardiovascular Diseases, Inflammation, Necrosis, Nervous System Diseases, Prostatic Neoplasms, Skin Diseases, Thrombosis are some of the diseases may be linked to Rat Anti-Mouse Dtk.