|The DUX4 dux4 (Catalog #MBS190936) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s DUX4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Formalin/Paraffin, Immunofluorescence (IF), Immunoblot (IB).
Immunohistochemistry: frozen or paraffin. Researchers should empirically determine the suitability of the DUX4 dux4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DUX4 dux4 product has the following accession number(s) (GI #300885357) (NCBI Accession #ADK45344.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the DUX4 Monoclonal Antibody with the following immunoassay(s):
Facioscapulohumeral muscular dystrophy (FSHD) is caused by the deletion of a subset of D4Z4 macro-satellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epi-genetically suppressed in differentiated tissues, and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues.
Antigen: C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag. Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DUX4 are readily searchable from our website. Different antibodies against the same target such as DUX4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.