Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Monoclonal Antibody Blog  rightarrow anti-EIF2AK3 antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • anti-C4.4A antibody blog
 • anti-D-Dimer antibody blog
 • anti-TPA antibody blog
 • anti-Norovirus antibody blog
 • anti-VAMP1 antibody blog
 • anti-LPAM-1 antibody blog
 • anti-LRP1 antibody blog
 • anti-S100A3 antibody blog
 • anti-PTH antibody blog
 • anti-Snca antibody blog
 • anti-AACT antibody blog
 • anti-CD32 antibody blog
 • anti-CD104 antibody blog
 • anti-FOSL1 antibody blog
 • anti-HO-1 antibody blog
 • anti-IgE antibody blog
 • anti-WASF1 antibody blog
 • anti-AmCyan-tag antibody blog
 • anti-Helicobacter pylori antibody blog
 • anti-MMP23B antibody blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • RMDN1 Antibody
 • IL12 Antibody
 • Raf-1 (Ser642) (RAF1) Antibody
 • Soluble programmed death-1 (sPD-1) ELISA Kit
 • Gastric inhibitory polypeptide (GIP) ELISA Kit
 • ATP synthase subunit delta, mitochondrial (ATP5D) Recombinant Protein
 • E. coli (O & K antigens) Antibody
 • Lysophosphatidylcholine (LPC) ELISA Kit
 • Free Tri-Iodothyronine (FREE-T3) ELISA Kit
 • FZD8 ELISA Kit
 • anti-cyclic citrullinated peptide antibody (anti-CCP antibod... ELISA Kit
 • QKI Recombinant Protein
 • LDH Antibody
 • Hepatitis B Antibody
 downarrow more ...
separator

anti-EIF2AK3 antibody product blog

separator
Posted on 2016-06-17 08:35:49 by mybiosource_staff
Share it on ...     
separator
separator
Tags: Antibody; Monoclonal Antibody; anti-EIF2AK3 antibody; EIF2AK3;
separator
The EIF2AK3 eif2ak3 (Catalog #MBS9217062) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The EIF2AK3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s EIF2AK3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).
WB:~~1:250-1:1000. Researchers should empirically determine the suitability of the EIF2AK3 eif2ak3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The EIF2AK3 eif2ak3 product has the following accession number(s) (GI #134304838) (NCBI Accession #NP_004827.4) (Uniprot Accession #Q9NZJ5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the EIF2AK3 Antibody with the following immunoassay(s):
Western Blot (WB) (All lanes : Anti-EIF2AK3 Antibody at 1:250-1:1000 dilution
Lane 1: A549 whole cell lysate
Lane 2: PC-12 whole cell lysate
Lane 3: mouse brain lysate
Lane 4: mouse liver lysate
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 125 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB) EIF2AK3.

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1(CCND1). Involved in control of mitochondrial morphology and function (By similarity).

Cellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2Sl) on \'Ser-52\' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2Sl either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced Gl growth arrest due to the loss of cyclin-Dl (CCNDl). Involved in control of mitochondrial morphology and function.
Tissue Location: Ubiquitous. A high level expression is seen in secretory tissues. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing EIF2AK3 are readily searchable from our website. Different antibodies against the same target such as EIF2AK3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions