anti-EMAP-II antibody product blog
Tags: Antibody; Monoclonal Antibody; EMAP-II; anti-EMAP-II antibody;
The EMAP-II aimp1 (Catalog #MBS584124) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The EMAP-II, Human, mAb 546-2 reacts with Reactivity: Human. Cross reactivity: Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s EMAP-II can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunoassay (IA), P, Western Blot (WB).Application Use: For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. Researchers should empirically determine the suitability of the EMAP-II aimp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The EMAP-II aimp1 product has the following accession number(s) (GI #498910) (NCBI Accession #AAA62202.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Product Description: Monoclonal antibody 546-2 reacts with endothelial-monocyte-activating polypeptide II (EMAP II), a 20 kDa polypeptide. EMAP II is an antiangiogenic and proinflammatory cytokine (expressed by microglia/macrophages). EMAP II appears to be a profound modulator of inflammatory reactions of the innate immune system and might participate in a variety of pathogenic immune-processes in the mammalian brain. EMAP II is a potential mediator of inflammatory responses in autoimmunity and a considered target to stage reactions of monocytic lineage cells in inflammatory reactions. In normal tissues EMAP II is expressed in endocrine organs, in cells of neuroendocrine origin, but also in tissues with high cell turnover. Under pathophysiological conditions EMAP II has several functions. It triggers the recruitment of macrophages by elevating cytosolic-free Ca2+ concentrations, it stimulates leukocyte chemotaxis, it induces the expression of TNF-alpha and tissue factor (TF) by monocytes and myeloperoxidase (MPO) by polymorphonuclear cells (PNMs). Furthermore it stimulates the release of von Willebrand-factor, P- and E-selectin by endothelial cells and EMAP II induces endothelial programmed cell death in vitro. The monoclonal antibody 546-2 is cross reactive with rat endothelial-monocyte-activating polypeptide II (rat EMAP II).
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing EMAP-II are readily searchable from our website. Different antibodies against the same target such as EMAP-II may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.